Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Phytol-based novel adjuvants in vaccine formulation: 2. assessment of efficacy in the induction of protective immune responses to lethal bacterial infections in mice. | Journal of Immune Based Therapies and Vaccines BioMed Central Open Access Original research Phytol-based novel adjuvants in vaccine formulation 2. assessment of efficacy in the induction of protective immune responses to lethal bacterial infections in mice So-Yon Lim1 Adam Bauermeister1 Richard A Kjonaas2 and Swapan K Ghosh 1 Address Department of Life Sciences Indiana State University Terre Haute IN 47809 USA and 2Department of Chemistry Indiana State University Terre Haute IN 47809 USA Email So-Yon Lim - slim@ Adam Bauermeister - abauerm2@ Richard A Kjonaas - rkjonaas@ Swapan K Ghosh - sghosh@ Corresponding author Published 23 October 2006 Received 20 September 2006 Journal of Immune Based Therapies and Vaccines 2006 4 5 doi 1476-8518-4-5 This article is available from http content 4 1 5 Accepted 23 October 2006 2006 Lim et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Adjuvants are known to significantly enhance vaccine efficacy. However commercial adjuvants often have limited use because of toxicity in humans. The objective of this study was to determine the comparative effectiveness of a diterpene alcohol phytol and its hydrogenated derivative PHIS-01 relative to incomplete Freund s adjuvant IFA a commonly used adjuvant in augmenting protective immunity in mice against E. coli and S. aureus and in terms of inflammatory cytokines. Methods Vaccines consisting of heat-attenuated E. coli or S. aureus and either of the two phytol-based adjuvants or IFA were tested in female BALB c mice. The vaccines were administered intraperitoneally at 10-day intervals. The efficacy of the phytol and PHIS-01 as compared to .
