Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Age-related waning of in vitro Interferon-γ levels against r32kDaBCG in BCG vaccinated children. | Journal of Immune Based Therapies and Vaccines BioMed Central Original research Age-related waning of in vitro Interferon-Y levels against r32kDaBCG in BCG vaccinated children B Anuradha1 3 CM Santosh2 V Hari Sai Priya3 G Suman Latha3 KJR Murthy3 and Valluri Vijaya Lakshmi 1 3 Open Access Address LEPRA Society - Blue Peter Research Center Hyderabad AP India 2Center for DNA Finger printing and Diagnosis Hyderabad AP India and 3Bhagwan Mahavir Medical Research Centre Hyderabad AP India Email B Anuradha - anu_sri1@ CM Santosh - santosh@ V Hari Sai Priya - priyapriya_hs123@ G Suman Latha - sumanlathag@ KJR Murthy - kollurijrm@ Valluri Vijaya Lakshmi - vijayavalluri@ Corresponding author Published 7 June 2007 Received 24 April 2007 Journal of Immune Based Therapies and Vaccines 2007 5 8 doi l 476-8518-5-8 Accepted 7 June 2007 This article is available from http content 5 1 8 2007 Anuradha et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Mycobacterium bovis BCG vaccine has displayed inconsistent efficacy in different trials conducted in various geographical regions. Nevertheless it significantly reduces the risk of severe childhood tuberculosis and continues to be used to prevent tuberculosis in many countries. Many studies revealed that efficacy of vaccine wanes with age. Most of the studies were based on in vivo and in vitro responses to tuberculin. With the advent of newer tests such as in vitro interferon-Y assays and identification of potent immunogenic mycobacterial proteins there is a need to corroborate the observations. This study aims at ascertaining the need for a booster at a later age as .
