Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Acute disseminated encephalomyelitis mimicking late CNS relapse of acute lymphoblastic leukaemia: case report. | Journal of Medical Case Reports BioMed Central Open Access Case report Acute disseminated encephalomyelitis mimicking late CNS relapse of acute lymphoblastic leukaemia case report Ram Kumar 1 Shobha Nijalingappa1 John Grainger2 and Omar Ismayl1 Address Department of Paediatric Neurology Royal Manchester Children s Hospital Hospital Road Manchester UK and 2Department of Paediatric Haematology and Oncology Royal Manchester Children s Hospital Hospital Road Manchester UK Email Ram Kumar - kumarr1@ Shobha Nijalingappa - drshobha77@ John Grainger - Omar Ismayl - oismayl@ Corresponding author Published 9 February 2007 Received 22 January 2007 . . Accepted 9 February 2007 Journal of Medical Case Reports 2007 1 4 doi 1752-1947-1-4 This article is available from http content 1 1 4 2007 Kumar et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Acute encephalomyelopathy occurring after an allogeneic bone marrow transplant for leukaemia is a diagnostic emergency. The diagnosis can be challenging since there is a wide set of alternative diagnoses including opportunistic infections and relapse of the leukaemia. Case presentation A 13-year old girl presented with a severe acute myelopathy and encephalopathy. She was in prolonged remission from a central nervous system and bone marrow relapse of an acute lymphoblastic leukaemia treated with allogeneic bone marrow transplantation. Neuroimaging showed multifocal grey and white matter lesions of demyelinating appearance in the brain and entire spine. Immunophenotyping and cytogenetic investigations of the girl s cerebrospinal fluid lymphocytosis excluded a late central .
