Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: MeRy-B: a web knowledgebase for the storage, visualization, analysis and annotation of plant NMR metabolomic profiles | Ferry-Dumazet et al. BMC Plant Biology 2011 11 104 http 1471-2229 11 104 BMC Plant Biology DATABASE Open Access MeRy-B a web knowledgebase for the storage visualization analysis and annotation of plant NMR metabolomic profiles 1 f 1 Hélène Ferry-Dumazet Laurent Gil Catherine Deborde Annick Moing Stéphane Bernillon Dominique Rolin4 Macha Nikolski5 Antoine de Daruvar1 5 and Daniel Jacob1 2 3f Abstract Background Improvements in the techniques for metabolomics analyses and growing interest in metabolomic approaches are resulting in the generation of increasing numbers of metabolomic profiles. Platforms are required for profile management as a function of experimental design and for metabolite identification to facilitate the mining of the corresponding data. Various databases have been created including organism-specific knowledgebases and analytical technique-specific spectral databases. However there is currently no platform meeting the requirements for both profile management and metabolite identification for nuclear magnetic resonance NMR experiments. Description MeRy-B the first platform for plant 1H-NMR metabolomic profiles is designed i to provide a knowledgebase of curated plant profiles and metabolites obtained by NMR together with the corresponding experimental and analytical metadata ii for queries and visualization of the data iii to discriminate between profiles with spectrum visualization tools and statistical analysis iv to facilitate compound identification. It contains lists of plant metabolites and unknown compounds with information about experimental conditions the factors studied and metabolite concentrations for several plant species compiled from more than one thousand annotated NMR profiles for various organs or tissues. Conclusion MeRy-B manages all the data generated by NMR-based plant metabolomics experiments from description of the biological source to identification of the metabolites and determinations of
