Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Addison’s disease presenting with idiopathic intracranial hypertension in 24-year-old woman: a case report. | Sharma et al. Journal of Medical Case Reports 2010 4 60 http content 4 1 60 jAg JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Addison s disease presenting with idiopathic intracranial hypertension in 24-year-old woman a case report Dushyant Sharma1 Rohini Mukherjee1 Peter Moore2 Daniel J Cuthbertson1 Abstract Introduction Idiopathic intracranial hypertension can rarely be associated with an underlying endocrine disorder such as Cushing s syndrome hyperthyroidism or with administration of thyroxine or growth hormone. Though cases of idiopathic intracranial hypertension associated with Addison s disease in children have been reported there is only one documented case report of this association in adults. We describe a case of an acute adrenal insufficiency precipitated by idiopathic intracranial hypertension in a Caucasian female. Case presentation A 24-year-old Caucasian woman was acutely unwell with a background of several months of generalised fatigue and intermittent headaches. She had unremarkable neurological and systemic examination with a normal computerised tomography and magnetic resonance imaging of the brain. Normal cerebrospinal fluid but increased opening pressure at lumbar puncture suggested intracranial hypertension. A flat short synacthen test and raised level of adrenocorticotrophic hormone were consistent with primary adrenal failure. Conclusion Addison s disease can remain unrecognised until precipitated by acute stress. This case suggests that idiopathic intracranial hypertension can rarely be associated with Addison s disease and present as an acute illness. Idiopathic intracranial hypertension is possibly related to an increase in the levels of arginine vasopressin peptide in serum and cerebrospinal fluid secondary to a glucocorticoid deficient state. Introduction Idiopathic intracranial hypertension IIH describes the clinical syndrome of raised intracranial pressure in the absence of space-occupying .
