Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Pica in iron deficiency: a case series | Khan and Tisman Journal of Medical Case Reports 2010 4 86 http content 4 1 86 jAc JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Pica in iron deficiency a case series Yasir Khan1 2 Glenn Tisman1 Abstract Introduction Pica is an unusual condition where patients develop cravings for non-nutritive substances that can cause significant health risks. We report three patients with pica two of them showing evolutionary changes associated with pica and the third demonstrating a peculiar nature of pica which has yet to be reported. Case presentation We describe three patients who presented with symptoms of pica. The first patient is a 36-year-old Caucasian woman who had dysfunctional uterine bleeding associated with daily ingestion of two supersized cups of ice as iced tea. The second patient is a 62-year-old Caucasian man who presented with bleeding from colonic polyps associated with drinking partially frozen bottled water. Lastly the third patient a 37-year-old Hispanic woman presented with dysfunctional uterine bleeding and habitually chewed rubber bands. All three patients presented with hematological parameters diagnostic for iron deficiency anemia. Conclusion Pica has been practiced for centuries without a clear etiology. We have noticed that the younger community of academic and community physicians are not aware of the importance of complaints related to pica. None of our patients we describe here as well as their primary care physicians were aware of the importance of their pica related symptoms. Pica symptoms abated in one of our patients upon iron supplementation while the other two are currently under treatment as of this writing. We believe pica is an important sign of iron deficiency that should never be ignored and the craving for any unusual substance should compel clinicians to search for occult blood loss with secondary iron deficiency. Introduction Pica is an unusual craving for and ingestion of either edible or .