Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Five-year follow-up of Japanese patients with Paget's disease of the bone after treatment with low-dose oral alendronate: a case series. | Iba et al. Journal of Medical Case Reports 2010 4 166 http content 4 1 166 jA CASE REPORTS CASE REPORT Open Access Five-year follow-up of Japanese patients with Paget s disease of the bone after treatment with low-dose oral alendronate a case series Kousuke Iba 1 JunichiTakada2 Takuro Wada1 and Toshihiko Yamashita1 Abstract Introduction Paget s disease of the bone is characterized by focal abnormalities of increased bone turnover affecting one or more sites throughout the skeleton. Although this disease is rare in Japan it is common in western and southern Europe and among British migrants in Australia and New Zealand. Bisphosphonates have been widely used for the treatment of Paget s disease of the bone and are considered to be the treatment of choice. However there have been few reports on the long-term follow-up examination of patients after their treatment with bisphosphonates. Case presentation We report the treatment with a low dose of oral alendronate 5 mg per day which was effective in reducing bone turnover and pain over the five-year follow-up period in two Japanese patients a 66-year-old man and a 68-year-old woman with Paget s disease of the bone. Furthermore in one patient no clinical symptoms such as bone pain or increases in serum total alkaline phosphatase and urinary N-terminal telopeptide of type I collagen as markers of bone turnover were observed over the patient s five-year follow-up period. Conclusions To the best of our knowledge this is the first report of a long-term follow-up of patients with Paget s disease of the bone after a six-month treatment with low-dose oral alendronate 5 mg per day . Introduction Paget s disease of the bone PDB is characterized by focal abnormalities of increased bone turnover affecting one or more sites throughout the skeleton 1 . Although this disease is rare in Japan 2 3 it is common in western and southern Europe and among British migrants in Australia and New .
