Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Abnormal macrophage response to microbial stimulus in a 43-year-old man with a severe form of atherosclerosis: a case report. | Conti et al. Journal of Medical Case Reports 2010 4 183 http content 4 1 183 jAg JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Abnormal macrophage response to microbial stimulus in a 43-year-old man with a severe form of atherosclerosis a case report 1 2 3 2 2 4 2 Maria Conti Francesca Sanna Giulia AM Farci Sabrina Uda Giovanna Porcu Maria Collu Rosa R Bonatesta Barbara Batetta 2 Abstract Introduction New evidence indicates infections are emerging as risk factors for atherosclerosis although their specific role in the development and progression of atherosclerosis is still unclear. Case presentation A 43-year-old Caucasian man who had been treated for four years for multiple sclerosis progressively manifested systemic hypertension polycythemia peripheral arterial occlusion with intermittent claudication and persistent headaches. In 2006 an instrumental analysis magnetic resonance imaging of our patient revealed widespread fibrocalcific atherosclerotic lesions which accounted for all his current symptoms including those related to microbial stimulus. Two particular aspects were of interest namely a lack of conventional cardiovascular risk factors and a negative family history for cardiovascular events. His chemical blood tests all yielded negative findings although a low positive hepatitis C virus-ribonucleic acid titer was detected. The titer had progressively increased and worsening atherosclerosis threatened the life of our patient. Interferon therapy was not appropriate for our patient due to the severe adverse effects observed shortly after its administration. Conclusions The reaction of individual cells to infections may provide an explanation as to why individuals with a similar microbial burden corrected for the presence of other risk factors display a different susceptibility to developing or worsening atherosclerosis. The identification of susceptible individuals and the treatment even of silent infections may .
