Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Genome informatics: advances in theory and practice | Fu and Horton Genome Medicine 2010 2 7 http content 2 1 7 w Genome Medicine MEETING REPORT L Genome informatics advances in theory and practice Szu-chin Fu and Paul Horton Abstract A report on the 20th International Conference on Genome Informatics Yokohama Japan 14-16 December 2009. Introduction In December 2009 323 people from 11 countries attended the 20th annual International Conference on Genome Informatics also known as GIW from its former moniker the Genome Informatics Workshop . GIW is both a venerable and a timely conference. Venerable because it boasts an almost 20 year history as a venue to report advances in bioinformatics - yet also timely as we head into the era of personal genomics. The authors of this report are a similar mixture one of us is fortunate to have the distinction of presenting at the very first GIW while the other can see things with fresher eyes. Together we attempt to summarize some of the results presented at GIW 2009. Informatics for next-generation sequencing Primary data analysis Kouichi Kimura and Asako Koike Central Research Laboratory Hitachi Ltd Kokubunji Japan received one of two best paper awards with a novel localized data structure for suffix arrays which are a way of enabling efficient searching of large amounts of text such as genome sequences. This new structure efficiently combines lexical information which makes suffix arrays so powerful and flexible for string matching with the positional information needed for tasks such as genomic mapping of pair-end reads or sequences produced by splicing events or chaining nearby short exact matches for gapped alignment. In addition to being theoretically elegant they demonstrated that the method can increase the speed of mapping pair-end reads by a factor of two to three. Correspondence Szu-chin Fu. Email Paul Horton. Email horton-p@ Computational Biology Research Center AIST and The University of Tokyo Graduate .
