Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The role of complex genomic alterations in neuroblastoma risk estimation | Fischer and Berthold Genome Medicine 2010 2 31 http content 2 5 31 Genome Medicine MINIREVIEW L__ The role of complex genomic alterations in neuroblastoma risk estimation Matthias Fischer and Frank Berthold Abstract Specific genomic alterations such as loss of the chromosomal region 11q or amplification of the oncogene MYCN are well established markers of poor outcome in neuroblastoma. The advent of microarraybased comparative genomic hybridization array-CGH has enabled the analysis of pangenomic alteration profiles in the cancer genome offering the possibility of identifying new prognostic markers from complex aberration patterns. Results from recent studies examining large primary neuroblastoma cohorts by array-CGH show that global genomic profiles may add significant prognostic information. Here we discuss potential implications for risk estimation of neuroblastoma patients in clinical practice as well as for the understanding of neuroblastoma pathogenesis. The clinical heterogeneity of neuroblastoma Neuroblastoma a pediatric malignancy of the developing sympathetic nervous system is a multifaceted disease with biological and clinical courses ranging from relentless progression to spontaneous regression or differentiation into benign ganglioneuroma. Given these different phenotypes therapeutic regimens vary between wait-and-see approaches to the most intense multimodal treatment. Accurate prediction of the natural clinical course of each individual patient at the time of diagnosis is therefore an essential prerequisite for therapeutic decision-making. Clinical variables such as stage of the disease and age of the patient at diagnosis are well established predictors of neuroblastoma outcome. In addition non-random cytogenetic aberrations have been shown to be associated with clinical courses in neuroblastoma and are increasingly used in risk stratification systems Correspondence Department of Pediatric .
