Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine | Kim and Orkin Genome Medicine 2011 3 75 http content 3 11 75 w Genome Medicine REVIEW L_ Embryonic stem cell-specific signatures in cancer insights into genomic regulatory networks and implications for medicine Jonghwan Kim1 and Stuart H Orkin2 Abstract Embryonic stem ES cells are of great interest as a model system for studying early developmental processes and because of their potential therapeutic applications in regenerative medicine. Obtaining a systematic understanding of the mechanisms that control the stemness - self-renewal and pluripotency -of ES cells relies on high-throughput tools to define gene expression and regulatory networks at the genome level. Such recently developed systems biology approaches have revealed highly interconnected networks in which multiple regulatory factors act in combination. Interestingly stem cells and cancer cells share some properties notably selfrenewal and a block in differentiation. Recently several groups reported that expression signatures that are specific to ES cells are also found in many human cancers and in mouse cancer models suggesting that these shared features might inform new approaches for cancer therapy. Here we briefly summarize the key transcriptional regulators that contribute to the pluripotency of ES cells the factors that account for the common gene expression patterns of ES and cancer cells and the implications of these observations for future clinical applications. Embryonic stem cells cancer and genomic regulation Embryonic stem ES cells are cultured cells derived from the inner cell mass of the blastocyst-stage embryo 1 2 . They exhibit two distinct properties self-renewal the Correspondence stuart_orkin@ 2Department of Pediatric Oncology Children s Hospital and Dana Farber Cancer Institute Harvard Stem Cell Institute Harvard Medical School Howard Hughes Medical Institute Boston MA 02115 USA Full list of author information is available at the end of the .
