Thuốc chống muỗi mạnh từ lá cây bạch đàn và Vitex N, N-diethyl-m-toluamide (DEET), đó là một không thấm thương mại chống lại muỗi, có nhiều bất lợi như một mùi khó chịu, sự thâm nhập da, và gây ung thư. Chúng tôi đã khám phá thuốc chống thay thế mà không có hạn chế như vậy. Thuốc chống mới, p-menthane-3,8-diols (cis và trans), được phân lập từ lá bạch đàn citriodora. | 11 Potent Mosquito Repellents from the Leaves of Eucalyptus and Vitex Plants Hiroyuki Nishimura and Atsushi Satoh CONTENT Mosquito Repellent from Eucalyptus Oils Mosquito Repellent from E. citriodora Oil Mosquito Repellent from E. camaldulensis Oil New Natural Mosquito Repellent from Vitex rotundifolia References ABSTRACT N N-Diethyl-m-toluamide DEET which is a commercially available repellent against mosquitoes has many disadvantages such as an unpleasant odor skin penetration and carcinogenicity. We have explored alternative repellents without such drawbacks. New repellents p-menthane-3 8-diols cis and trans were isolated from the leaves of Eucalyptus citriodora. Especially the pentanoyl C5 and caproyl C6 esters of the diols exhibited much higher activity than DEET in terms of repellency and repellent durability against mosquitoes Aedes albopictus and Culex pipiens. In addition -eucamalol 1R 6R - -3-formyl-6-isopropyl-2-cyclohexene-1-ol which is a new mosquito repellent was isolated from E. camaldulensis leaves. The absolute configuration was determined by synthesizing from S - - -perillaldehyde. While from information of the traditional usage of Vitex rotundifolia for repelling mosquitoes at the southern part of Japan we tried to isolate a mosquito repellent from the leaves. As a result a cyclopentene dialdehyde named rotundial was identified. Mosquito Repellent from Eucalyptus 0ils As a postdoctoral fellow at the University of California Berkeley 1975 to 1977 I became interested in research on Eucalyptus oil Nishimura 1995 . One day I noticed that mosquitoes never appeared at the staff barbecues held near the Eucalyptus groves surrounding the campus. While enjoying the barbecues I could smell Eucalyptus volatiles in the air and I observed that the volatile chemicals from Eucalyptus leaves repelled mosquitoes quite a distance from the groves. N N-Diethyl-m-toluamide DEET has been used as a .
