Tổn thương thần kinh ngoại vi là phổ biến, và không có công thức dễ dàng có sẵn để điều trị thành công. Thương tích không đầy đủ là thường xuyên nhất. Seddon phân loại tổn thương thần kinh thành ba loại: neurapraxia, axonotmesis, và neurotmesis. Sau khi hoàn thành transection sợi trục | Peripheral Nerve Injury and Repair Steve K. Lee MD and Scott W. Wolfe MD Abstract Peripheral nerve injuries are common and there is no easily available formula for successful treatment. Incomplete injuries are most frequent. Seddon classified nerve injuries into three categories neurapraxia axonotmesis and neurotmesis. After complete axonal transection the neuron undergoes a number of degenerative processes followed by attempts at regeneration. A distal growth cone seeks out connections with the degenerated distal fiber. The current surgical standard is epineurial repair with nylon suture. To span gaps that primary repair cannot bridge without excessive tension nerve-cable interfascicular autografts are employed. Unfortunately results of nerve repair to date have been no better than fair with only 50 of patients regaining useful function. There is much ongoing research regarding pharmacologic agents immune system modulators enhancing factors and entubulation chambers. Clinically applicable developments from these investigations will continue to improve the results of treatment of nerve injuries. J Am Acad Orthop Surg 2000 8 243-252 Peripheral nerves were first distinguished from tendons by Heroph-ilus in 300 BC. By meticulous dissection he traced nerves to the spinal cord demonstrating the continuity of the nervous In 900 AD Rhazes made the first clear reference to nerve repair. However not until 1795 did Cruikshank demonstrate nerve healing and recovery of distal extremity function after repair. In the early 1900s Cajal pioneered the concept that axons regenerate from neurons and are guided by chemotrophic substances. In 1945 Sunderland promoted microsurgical techniques to improve nerve repair Since that time there have been a number of advances and new concepts in peripheral nerve reconstruction. Research regarding the molecular biology of nerve injury has expanded the available strategies for improving results. Some of these strategies .
