Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Gait dynamics in mouse models of Parkinson's disease and Huntington's disease | Journal of NeuroEngineering and Rehabilitation BioMed Central Research Open Access Gait dynamics in mouse models of Parkinson s disease and Huntington s disease Ivo Amende11 Ajit Kalet2 Scott McCue2 Scott Glazier2 James P Morgan1 and Thomas G Hampton 1 2 Address Division of Medicine Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA and 2The CuraVita Corporation Boston MA 02109 USA Email Ivo Amende - ivo@ Ajit Kale - ajit_kale@ Scott McCue - smccue@ Scott Glazier - James P Morgan - jmorgan@ Thomas G Hampton - hampton@ Corresponding author tEqual contributors Published 25 July 2005 Received 02 April 2005 Journal of NeuroEngineering and Rehabilitation 2005 2 20 doi 86 1743- Accepted 25 July 2005 0003-2-20 This article is available from http content 2 1 20 2005 Amende et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Gait is impaired in patients with Parkinson s disease PD and Huntington s disease HD but gait dynamics in mouse models of PD and HD have not been described. Here we quantified temporal and spatial indices of gait dynamics in a mouse model of PD and a mouse model of HD. Methods Gait indices were obtained in C57BL 6J mice treated with the dopaminergic neurotoxin 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine MPTP 30 mg kg day for 3 days for PD the mitochondrial toxin 3-nitropropionic acid 3NP 75 mg kg cumulative dose for HD or saline. We applied ventral plane videography to generate digital paw prints from which indices of gait and gait variability were determined. Mice walked on a transparent treadmill belt at a speed of 34 cm s after
