Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Multifocal hepatoblastoma in a 6-month-old girl with trisomy 18: a case report | JOURNAL OF MEDICAL Sr CASE REPORTS Open Access Case report Multifocal hepatoblastoma in a 6-month-old girl with trisomy 18 a case report Lidija Kitanovski1 Zdenka Ovcak2 and Janez Jazbec1 Addresses University Medical Centre Ljubljana Department of Pediatrics Hematooncology Division Vrazov trg 1 1000 Ljubljana Slovenia and 2Institute of Pathology Medical Faculty University of Ljubljana Korytkova 2 1000 Ljubljana Slovenia Email LK - ZO - JJ - Corresponding author Received 20 October 2008 Accepted 22 January 2009 Published 23 June 2009 Journal ofMedical Case Reports 2009 3 8319 doi 1752-1947-3-8319 This article is available from http jmedicalcasereports article view 8319 2009 Kitanovski et al licensee Cases Network Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Edward s syndrome trisomy 18 is a rare entity with a reported incidence of 1 3000 to 1 7000 births. Less than 10 of patients survive beyond the first year of life which may influence the fact that malignant tumors are rarely reported in association with this syndrome. Case presentation The authors report a rare case of a 6-month-old girl with trisomy 18 and multifocal hepatoblastoma. The course of the disease autopsy results and review of the literature are presented. Conclusion Our case represents the seventh published case of hepatoblastoma in a patient with trisomy 18. All of the seven published cases were women possibly due to the high preponderance of females among the children with Edward s syndrome and longer survival of females with trisomy 18 compared to males. Since both trisomy 18 and hepatoblastoma are rare conditions the probability that a child with
