Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Coxiella burnetii as a possible cause of autoimmune liver disease: a case report | JOURNAL OF MEDICAL Sr CASE REPORTS Open Access Case report Coxiella burnetii as a possible cause of autoimmune liver disease a case report Chloe Kaech1 Isabelle Pache2 Didier Raoult3 and Gilbert Greub1 4 Addresses 1Division of Infectious Diseases Centre Hospitalier Universitaire Vaudois 1011 Lausanne Switzerland 2Division of Gastroenterology Centre Hospitalier Universitaire Vaudois 1011 Lausanne Switzerland 3Unité des Rickettsies Faculté de Médecine Université de la Méditerranée Marseille France 4Institute of Microbiology University of Lausanne Lausanne Switzerland Email CK - IP - DR - GG - Corresponding author Received 2 January 2009 Accepted 2 March 2009 Published 10 August 2009 Journal of Medical Case Reports 2009 3 8870 doi 1752-1947-3-8870 This article is available from http jmedicalcasereports article view 8870 2009 Kaech et al. licensee Cases Network Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Q fever is a zoonotic infection that may cause severe hepatitis. Q-fever hepatitis has not yet been associated with autoimmune hepatitis and or primary biliary cirrhosis. Case presentation We describe a 39-year-old man of Sri Lankan origin with chronic Q-fever hepatitis who developed autoantibodies compatible with autoimmune hepatitis primary biliary cirrhosis overlap syndrome. Ursodeoxycholic acid in addition to antibiotic therapy markedly improved hepatic enzyme levels suggesting that autoimmunity potentially triggered by the underlying infection was involved in the pathogenesis of liver damage. Conclusion We suggest that Coxiella burnetii might trigger autoimmune liver disease. Patients with Q-fever .
