Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Stimulation dependent induction of fear and depression in deep brain stimulation: a case report | JOURNAL OF MEDICAL Sr CASE REPORTS Open Access Case report Stimulation dependent induction of fear and depression in deep brain stimulation a case report Michael Sabolek1 2 Ingo Uttner2 Klaus Seitz3 Eduard Kraft4 and Alexander Storch5 Addresses Department of Neurology EMA-University of Greifswald Greifswald Germany 2Department of Neurology University of Ulm Ulm Germany 3Department of Neurosurgery University of Ulm Gunzburg Germany 4Department of Physical Medicine and Rehabilitation Clinic GroBhadern University of Munich Munich Germany 5Department of Neurology Dresden University of Technology Dresden Germany Email MS - Corresponding author Received 16 June 2008 Accepted 30 April 2009 Published 11 September 2009 Journal of Medical Case Reports 2009 3 9136 doi 1752-1947-3-9136 This article is available from http jmedicalcasereports article view 9136 2009 Sabolek et al. licensee Cases Network Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Psychiatric side effects of deep brain stimulation are not uncommon. It is often limited to transient mood alterations. We report for the first time a case of acute stimulationdependent fear during intraoperative test stimulation. Case presentation During test stimulation for electrode placement to the left subthalamic nucleus a 58-year-old caucasian man with Parkinson s disease developed a severe reproducible feeling of fear together with elevated heart rate and sweating. Postoperatively the patient developed a therapy refractory major depression in spite of excellent motor-control. Reprogramming the stimulator using a more rostral contact resulted in an abrupt and complete disappearance of the depressive syndrome. Conclusion .
