Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The influence of psychiatric screening in healthy populations selection: a new study and metaanalysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits | Minelli et al. BMC Psychiatry 2011 11 50 http 1471-244X 11 50 BMC Psychiatry RESEARCH ARTICLE Open Access The influence of psychiatric screening in healthy populations selection a new study and metaanalysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits 1 s r-x 1 1 2 Alessandra Minelli Cristian Bonvicini Catia Scassellati Riccardo Sartori and Massimo Gennarelli Abstract Background A genetic liability for anxiety-related personality traits in healthy subjects has been associated with the functional serotonin transporter promoter polymorphism 5-HTTLPR although the data are somewhat conflicting. Moreover only one study has investigated the functional significance of the 5-HTTLPR rs25531 haplotypes in relation to anxiety traits in healthy subjects. We tested whether the 5-HTTLPR polymorphism and the 5-HTTLPR rs25531 haplotypes are linked to Harm Avoidance HA using an association study STUDY I and a meta-analytic approach STUDY II . Methods STUDY I A total of 287 unrelated Italian volunteers were screened for DSM-IV Axis I disorders and genotyped for the 5-HTTLPR and rs25531 A G polymorphisms. Different functional haplotype combinations were also analyzed. STUDY II A total of 44 studies were chosen for a meta-analysis of the putative association between 5-HTTLPR and anxiety-related personality traits. Results STUDY I In the whole sample of 287 volunteers we found that the SS genotype and S S haplotypes were associated with higher scores on HA. However because the screening assessed by Mini-International Neuropsychiatric Interview . showed the presence of 55 volunteers affected by depression or anxiety disorders we analyzed the two groups disordered and healthy separately. The data obtained did indeed confirm that in the healthy group the significant effects of the SS genotype and S S haplotypes were lost but they remained in the disordered group. STUDY II The results of the 5-HTTLPR meta-analysis
