Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Relation between therapeutic response and side effects induced by methylphenidate as observed by parents and teachers of children with ADHD | Lee et al. BMC Psychiatry 2011 11 70 http 1471-244X 11 70 BMC Psychiatry RESEARCH ARTICLE Open Access Relation between therapeutic response and side effects induced by methylphenidate as observed by parents and teachers of children with ADHD I m Z r I z r 1 I 4 I Z i . lzz 1 4 z lz i 4 K S m n m o p. s 4 1 4 c v I I I Z t I I k .4 4 A D r I r 1 4 s u . zd James Lee Natalie GrizenKo venKataramana Bhat Sarojini Sengupta Anna roiotsKaia ana Ridha Joober1 2 3 4 Abstract Background The desired therapeutic and undesired side effects of methylphenidate might have underlying correlations. The aim of this study was to explore the strength and the possible sources of these correlations. Methods One hundred and fifty-seven children with ADHD 6-12 years were administered placebo and methylphenidate mg Kg in a divided . dose each for a one-weeK period in a double-blind crossover trial. Therapeutic response was assessed using the Conners Global Index for parents CGI-Parents and teachers CGI-Teachers while side effects were assessed using the BarKley Side Effects Rating Scale SERS . Results The side effect profile as assessed by the SERS was similar to that of previous studies with insomnia decreased appetite and headaches showing significant treatment effects p . These somatic physical side effects did not correlate with CGI-Parents or CGI-Teachers. However the side effects of irritability proneness to crying and anxiousness showed significant relationships with CGI-Parents. These mood anxiety side effects showed no significant correlations with the CGI-Teachers. Conclusion The greater mood anxiety side effects on methylphenidate and placebo the less the parents observe improvement of their children while treated with methylphenidate. This suggests that the correlations between mood anxiety side effects and poor response to treatment may be driven by observer effects rather than biological commonalities between therapeutic and side effects of
