Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A comparative study on long-term evoked auditory and visual potential responses between Schizophrenic patients and normal subjects | Huang et al. BMC Psychiatry 2011 11 74 http 1471-244X 11 74 BMC Psychiatry RESEARCH ARTICLE Open Access A comparative study on long-term evoked auditory and visual potential responses between Schizophrenic patients and normal subjects Min-Wei Huang1 3 Frank Huang-Chih Chou2 Pei-Yu Lo1 and Kuo-Sheng Cheng1 Abstract Background The electrical signals measuring method is recommended to examine the relationship between neuronal activities and measure with the event related potentials ERPs during an auditory and a visual oddball paradigm between schizophrenic patients and normal subjects. The aim of this study is to discriminate the activation changes of different stimulations evoked by auditory and visual ERPs between schizophrenic patients and normal subjects. Methods Forty-three schizophrenic patients were selected as experimental group patients and 40 healthy subjects with no medical history of any kind of psychiatric diseases neurological diseases or drug abuse were recruited as a control group. Auditory and visual ERPs were studied with an oddball paradigm. All the data were analyzed by SPSS statistical software version . Results In the comparative study of auditory and visual ERPs between the schizophrenic and healthy patients P300 amplitude at Fz Cz and Pz and N100 N200 and P200 latencies at Fz Cz and Pz were shown significantly different. The cognitive processing reflected by the auditory and the visual P300 latency to rare target stimuli was probably an indicator of the cognitive function in schizophrenic patients. Conclusions This study shows the methodology of application of auditory and visual oddball paradigm identifies task-relevant sources of activity and allows separation of regions that have different response properties. Our study indicates that there may be slowness of automatic cognitive processing and controlled cognitive processing of visual ERPs compared to auditory ERPs in schizophrenic patients. The activation changes .
