Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Change in level of productivity in the treatment of schizophrenia with olanzapine or other antipsychotics | Liu-Seifert et al. BMC Psychiatry 2011 11 87 http 1471-244X 11 87 BMC Psychiatry RESEARCH ARTICLE Open Access Change in level of productivity in the treatment of schizophrenia with olanzapine or other antipsychotics Hong Liu-Seifert Haya Ascher-Svanum Olawale Osuntokun Kai Yu Jen and Juan Carlos Gomez Abstract Background When treating schizophrenia improving patients productivity level is a major goal considering schizophrenia is a leading cause of functional disability. Productivity level has been identified as the most preferred treatment outcome by patients with schizophrenia. However little has been done to systematically investigate productivity levels in schizophrenia. We set out to better understand the change in productivity level among chronically ill patients with schizophrenia treated with olanzapine compared with other antipsychotic medications. We also assessed the links between productivity level and other clinical outcomes. Methods This post hoc analysis used data from 6 randomized double-blind clinical trials of patients with schizophrenia or schizoaffective disorder with each trial being of approximately 6 months duration. Change in productivity level was compared between olanzapine-treated patients HGBG n 172 HGHJ n 277 HGJB n 171 HGLB n 281 HGGN n 159 HGDH n 131 and patients treated with other antipsychotic medications separately vs. haloperidol HGGN n 97 HGDH n 132 risperidone HGBG n 167 HGGN n 158 quetiapine HGJB n 175 ziprasidone HGHJ n 271 and aripiprazole HGLB n 285 . Productivity was defined as functional activities work including working for pay studying housekeeping and volunteer work. Productivity level in the prior 3 months was assessed on a 5-point scale ranging from no useful functioning to functional activity work 75 to 100 of the time. Results Chronically ill patients treated with olanzapine OLZ experienced significantly greater improvement in productivity when compared to patients treated with risperidone RISP
