Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Substance abuse and psychiatric co-morbidity as predictors of premature mortality in Swedish drug abusers a prospective longitudinal study 1970 - 2006 | Nyhlén et al. BMC Psychiatry 2011 11 122 http 1471-244X 11 122 BMC Psychiatry RESEARCH ARTICLE Open Access Substance abuse and psychiatric co-morbidity as predictors of premature mortality in Swedish drug abusers a prospective longitudinal study 1970 - 2006 Anna Nyhlén1 Mats Fridell2 Martin Backstrom3 Morten Hesse4 and Peter Krantz5 Abstract Background Few longitudinal cohort studies have focused on the impact of substances abused and psychiatric disorders on premature mortality. The aim of the present study was to identify predictors of increased risk of drug related death and non drug related death in substance abusers of opiates stimulants cannabis sedatives hypnotics hallucinogens and alcohol over several decades. Methods Follow-up study of a consecutive cohort of 561 substance abusers admitted to a detoxification unit January 1970 to February 1978 in southern Sweden and followed up in 2006. Demographic and clinical data substance diagnoses and three groups of psychiatric diagnoses were identified at first admission. Causes of death were coded according to ICD-10 and classified as drug related deaths or non drug related deaths. To identify the incidence of some probable risk factors of drug related premature death the data were subjected to a competing risks Cox regression analysis. Results Of 561 patients in the cohort 11 individuals had either emigrated or could not be located and 204 561 patients were deceased by 2006. The cumulative risk of drug related death increased more in the first 15 years and leveled out later on when non drug related causes of death had a similar incidence. In the final model male gender regular use of opiates or barbiturates at first admission and neurosis were associated with an increased risk of drug related premature death while cannabis use and psychosis were associated with a decreased risk. Neurosis mainly depression and or anxiety disorders predicted drug related premature death while chronic .
