Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Comparative efficacy of the Cognitive Behavioral Analysis System of Psychotherapy versus Supportive Psychotherapy for early onset chronic depression: design and rationale of a multisite randomized controlled trial | Schramm et al. BMC Psychiatry 2011 11 134 http 1471-244X 11 134 BMC Psychiatry STUDY PROTOCOL Open Access Comparative efficacy of the Cognitive Behavioral Analysis System of Psychotherapy versus Supportive Psychotherapy for early onset chronic depression design and rationale of a multisite randomized controlled trial 1 2 1 3 1 3 Elisabeth Schramm Martin Hautzinger Ingo Zobel Levente Kriston Mathias Berger and Martin Harter Abstract Background Effective treatment strategies for chronic depression are urgently needed since it is not only a common and particularly disabling disorder but is also considered treatment resistant by most clinicians. There are only a few studies on chronic depression indicating that traditional psycho- and pharmacological interventions are not as effective as in acute episodic depression. Current medications are no more effective than those introduced 50 years ago whereas the only psychotherapy developed specifically for the subgroup of chronic depression the Cognitive Behavioral Analysis System of Psychotherapy CBASP faired well in one large trial. However CBASP has never been directly compared to a non-specific control treatment. Methods Design The present article describes the study protocol of a multisite parallel-group randomized controlled trial in Germany. The purpose of the study is to estimate the efficacy of CBASP compared to supportive psychotherapy in 268 non-medicated early-onset chronically depressed outpatients. The intervention includes 20 weeks of acute treatment with 24 individual sessions followed by 28 weeks of continuation treatment with another 8 sessions. Depressive symptoms are evaluated 20 weeks after randomisation by means of the 24-item Hamilton Rating Scale of Depression HRSD . Secondary endpoints are depressive symptoms after 12 and 48 weeks and remission after 12 20 and 48 weeks. Primary outcome will be analysed using analysis of covariance ANCOVA controlled for pre-treatment scores and .
