Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Environmental exposures and their genetic or environmental contribution to depression and fatigue: a twin study in Sri Lanka | Ball et al. BMC Psychiatry 2010 10 13 http 1471-244X 10 13 BMC Psychiatry RESEARCH ARTICLE Open Access Environmental exposures and their genetic or environmental contribution to depression and fatigue a twin study in Sri Lanka I_l- rri - A D I I 1C I r- I r I_I c I ri S 2 p I 11 c I I m A I k- . s I -s2 3 i I I I s r- 1 4 I I s ls f _ I z .-z .k 5 6 k h K I lííỉk-x1 Harriet A Ball Sisira H Siribaddana Atnula sumathipala Yulia Kovas NICK Glozier peter Mcuurrin Matthew Hotopf6 Abstract Background There is very little genetically informative research identifying true environmental risks for psychiatric conditions. These may be best explored in regions with diverse environmental exposures. The current study aimed to explore similarities and differences in such risks contributing to depression and fatigue. Methods Home interviews assessed depression lifetime-ever fatigue and environmental exposures in 4 024 randomly selected twins from a population-based register in the Colombo district of Sri Lanka. Results Early school leaving and standard of living showed environmentally-mediated effects on depression in men. In women life events were associated with depression partly through genetic pathways however the temporal order is consistent with life events being an outcome of depression as well as the other way around . For fatigue there were environmentally mediated effects through early school leaving and life events and strong suggestions of family-environmental influences. Conclusions Compared to previous studies from higher-income countries novel environmentally-mediated risk factors for depression and fatigue were identified in Sri Lanka. But as seen elsewhere the association between life events and depression was partially genetically mediated in women. These results have implications for understanding environmental mechanisms around the world. Background Classical twin studies can tell us the degree to which individual differences in a .