Báo cáo y học: " Model-based parametric study of frontostriatal abnormalities in schizophrenia patients"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Model-based parametric study of frontostriatal abnormalities in schizophrenia patients | Tanaka BMC Psychiatry 2010 10 17 http 1471-244X 10 17 BMC Psychiatry RESEARCH ARTICLE Open Access Model-based parametric study of frontostriatal abnormalities in schizophrenia patients Shoji Tanaka Abstract Background Several studies have suggested that the activity of the prefrontal cortex PFC and the dopamine DA release in the striatum has an inverse relationship. One would attribute this relationship primarily to the circuitry comprised of the glutamatergic projection from the PFC to the striatum and the GABAergic projection from the striatum to the midbrain DA nucleus. However this circuitry has not characterized satisfactorily yet so that no quantitative analysis has ever been made on the activities of the PFC and the striatum and also the DA release in the striatum. Methods In this study a system dynamics model of the corticostriatal system with dopaminergic innervations is constructed to describe the relationships between the activities of the PFC and the striatum and the DA release in the striatum. By taking published receptor imaging data from schizophrenia patients and healthy subjects into this model this article analyzes the effects of striatal D2 receptor activation on the balance of the activity and neurotransmission in the frontostriatal system of schizophrenic patients in comparison with healthy controls. Results The model predicts that the suppressive effect by D2 receptors at the terminals of the glutamatergic afferents to the striatum from the PFC enhances the hypofrontality-induced elevation of striatal DA release by at most 83 . The occupancy-based estimation of the optimum D2 receptor occupancy by antipsychotic drugs is 52 . This study further predicts that patients with lower PFC activity tend to have greater improvement of positive symptoms following antipsychotic medication. Conclusion This model-based parametric study would be useful for system-level analysis of the brains with psychiatric diseases. It will be able to

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