Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A Canadian naturalistic study of a communitybased cohort treated for bipolar disorder | Sagman et al. BMC Psychiatry 2010 10 24 http 1471-244X 10 24 BMC Psychiatry RESEARCH ARTICLE Open Access A Canadian naturalistic study of a communitybased cohort treated for bipolar disorder 1 3 4 1 Doron Sagman Bobbie Lee Ranjith Chandresena Barry Jones Elizabeth Brunner Abstract Background Bipolar illness is associated with significant psychosocial morbidity and health resource utilization. Second generation antipsychotics used alone or in combination with mood stabilizers are effective in treating acute mania in community settings. This study was designed to compare the change in clinical parameters and resource utilization at one month in a group of patients who required treatment intervention for exacerbation of mania. The clinical response at one year was also evaluated. Methods 496 patients were enrolled at 75 psychiatric practices across Canada. The Olanzapine cohort n 287 included patients who had olanzapine added to their medication regimen or the dose of olanzapine increased. The Other cohort n 209 had a medication other than olanzapine added or the dose adjusted. Changes from baseline in the Young Mania Rating Scale YMRS Montgomery Asberg Depression Rating Scale Beck Anxiety Inventory and SF-12 Health Survey were compared at one month using ANCOVA. Categorical variables at one month for health resource utilization employment status abuse dependency and the number of suicide attempts were compared using Fisher s Exact test. Patients were followed for one year and a subgroup was evaluated. Results At one month patients in the Olanzapine cohort recorded a mean reduction in the YMRS of significantly greater than the mean reduction in the Other cohort of ANCOVA P . The Olanzapine cohort was significantly improved compared to the Other cohort on the scales for depression and anxiety and did not experience the deterioration in physical functioning seen in the Other cohort. No significant differences were detected in .