Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: INCANT: a transnational randomized trial of Multidimensional Family Therapy versus treatment as usual for adolescents with cannabis use disorder | Rigter et al. BMC Psychiatry 2010 10 28 http 1471-244X 10 28 BMC Psychiatry STUDY PROTOCOL Open Access INiCANiT a transnational randomized trial of Multidimensional Family Therapy versus treatment as usual for adolescents with cannabis use disorder Henk Rigter 1 2 Isidore Pelc3 PeterTossmann4 Olivier Phan5 Esther Grichting6 Vincent Hendriks7 and Cindy Rowe8 Abstract Background In 2003 the governments of Belgium France Germany the Netherlands and Switzerland agreed that there was a need in Europe for a treatment programme for adolescents with cannabis use disorders and other behavioural problems. Based on an exhaustive literature review of evidence-based treatments and an international experts meeting Multidimensional Family Therapy MDFT was selected for a pilot study first which was successful and then for a joint transnational randomized controlled trial named INCANT INternational CAnnabis Need for Treatment . Methods design INCANT is a randomized controlled trial RCT with an open-label parallel group design. This study compares MDFT with treatment as usual TAU at and across sites in Brussels Berlin Paris The Hague and Geneva. Assessments are at baseline and at 3 6 9 and 12 months after randomization. A minimum of 450 cases in total is required sites will recruit 60 cases each in Belgium and Switzerland and a maximum of 120 each in France Germany and the Netherlands. Eligible for INCANT are adolescents from 13 through 18 years of age with a cannabis use disorder dependence or abuse with at least one parent willing to take part in the treatment. Randomization is concealed to and therefore beyond control by the researcher site requesting it. Randomization is stratified as to gender age and level of cannabis consumption. Assessments focus on substance use mental function behavioural problems and functioning regarding family school peers and leisure time. For outcome analyses the study will use state of the art latent growth curve modelling .