Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Comparison of ankle-brachial pressure index and pulse wave velocity as markers of cognitive function in a community-dwelling population | Sugawara et al. BMC Psychiatry 2010 10 46 http 1471-244X 10 46 BMC Psychiatry RESEARCH ARTICLE Open Access Comparison of ankle-brachial pressure index and pulse wave velocity as markers of cognitive function in a community-dwelling population Norio Sugawara 1 Norio Yasui-Furukori2 Takashi Umeda3 Ayako Kaneda2 Yasushi Sato1 Ippei Takahashi3 Masashi Matsuzaka3 Kazuma Danjo3 Shigeyuki Nakaji3 and Sunao Kaneko2 Abstract Background Vascular factors have been implicated in the development of cognitive decline and dementia. The purpose of this study is to determine the association of the Ankle Brachial pressure Index ABI and brachial-ankle Pulse Wave Velocity ba-PWV to cognitive impairment in a community-dwelling population. Methods The ABI and ba-PWV were measured using the volume-plethymographic apparatus in 388 subjects aged 60 years old and over. The Mini-Mental State Examination was also employed to measure global cognitive status. The effectiveness of the ABI and ba-PWV as putative markers of cognitive impairment were determined by using a multiple logistic regression analysis after adjusting for confounding factors. Results Subjects with poor cognition were significantly older and less well educated than those with normal cognition. According to the multiple logistic regression analysis the lowest ABI tertile was found to be a significant independent risk factor OR 95 CI to of the cognitive impairment whereas the highest brachial-ankle PWV tertile was not. Conclusions A low ABI was an independent risk factor for cognitive impairment in community-dwelling older populations whereas a high ba-PWV may not be. Further research will be required to analyze ABI and PWV with greater accuracy. Background The cognitive impairment is an important health issue contributing to disability 1 morbidity 2 and mortality 3 . The identification of clinical markers predicting cognitive impairment in elderly is often considered useful in easing the .