Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia | Selva-Vera et al. BMC Psychiatry 2010 10 47 http 1471-244X 10 47 BMC Psychiatry RESEARCH ARTICLE Open Access The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia Gabriel Selva-Vera 1 2 Vicent Balanza-Martinez1 2 José Salazar-Fraile1 2 José Sanchez-Moreno2 3 Anabel Martinez- Aran2 3 Patricia Correa1 2 Eduard Vieta 2 3 and Rafael Tabarés-Seisdedos 1 2 Abstract Background Atypical antipsychotics provide better control of the negative and affective symptoms of schizophrenia when compared with conventional neuroleptics nevertheless their heightened ability to improve cognitive dysfunction remains a matter of debate. This study aimed to examine the changes in cognition associated with longterm antipsychotic treatment and to evaluate the effect of the type of antipsychotic conventional versus novel antipsychotic drugs on cognitive performance over time. Methods In this naturalistic study we used a comprehensive neuropsychological battery of tests to assess a sample of schizophrenia patients taking either conventional n 13 or novel antipsychotics n 26 at baseline and at two years after. Results Continuous antipsychotic treatment regardless of class was associated with improvement on verbal fluency executive functions and visual and verbal memory. Patients taking atypical antipsychotics did not show greater cognitive enhancement over two years than patients taking conventional antipsychotics. Conclusions Although long-term antipsychotic treatment slightly improved cognitive function the switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of these cognitive deficits. Background Cognitive disturbances are a core feature of schizophrenia and have been extensively studied in recent years 1 . Cognitive impairment is present before the onset of the illness 2 and is also .
