Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Melancholic versus non-melancholic depression: differences on cognitive function. A longitudinal study protocol | Monzon et al. BMC Psychiatry 2010 10 48 http 1471-244X 10 48 BMC Psychiatry STUDY PROTOCOL Open Access Me lcincholic versus non-melancholic depression differences on cognitive function. A longitudinal study protocol Saray Monzon 1 2 Margalida Gili1 2 Margalida Vives1 2 Maria Jesus Serrano1 2 Natalia Bauza1 2 Rosa Molina1 3 Mauro García-Toro1 Joan Salvà1 Joan Llobera1 4 and Miquel Roca1 2 Abstract Background Cognitive dysfunction is common among depressed patients. However the pattern and magnitude of impairment during episodes of major depressive disorder MDD through to clinical remission remains unclear. Heterogeneity of depressive patients and the lack of longitudinal studies may account for contradictory results in previous research. Methods Design This longitudinal study will analyze cognitive differences between CORE-defined melancholic depressed patients n 60 and non-melancholic depressed patients n 60 . A comprehensive clinical and cognitive assessment will be performed at admission and after 6 months. Cognitive dysfunction in both groups will be longitudinally compared and the persistence of cognitive impairment after clinical remission will be determined. Discussion The study of neuropsychological dysfunction and the cognitive changes through the different phases of depression arise a wide variety of difficulties. Several confounding variables must be controlled to determine if the presence of depression could be considered the only factor accounting for group differences. Background Over the last years cognitive dysfunction has increasingly been recognized as a core feature of major depressive disorder MDD . Clinical studies have focused on the pattern and magnitude of impairment during and between episodes of MDD as well as the neuropsychological domains affected and the origin of these abnormalities 1 . However results from neuropsychological and neuroimaging studies are still controversial. These contradictory results could be .