Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effectiveness of psychotherapeutic, pharmacological, and combined treatments for chronic depression: a systematic review (METACHRON) | Kriston et al. BMC Psychiatry 2010 10 95 http 1471-244X 10 95 BMC Psychiatry STUDY PROTOCOL Open Access Effectiveness of psychotherapeutic pharmacological and combined treatments for chronic depression a systematic review METACHRON Levente Kriston1 Alessa von Wolff1 Lars Holzel2 Abstract Background Chronic depressions represent a substantial part of depressive disorders and are associated with severe consequences. Several studies were performed addressing the effectiveness of psychotherapeutic pharmacological and combined treatments for chronic depressions. Yet a systematic review comparing the effectiveness of multiple treatment options and considering all subtypes of chronic depressions is still missing. Methods Design Aim of this project is to summarize empirical evidence on efficacy and effectiveness of treatments for chronic depression by means of a systematic review. The primary objectives of the study are to examine which interventions are effective to examine if any differences in effectiveness between active treatment options exist and to find possible treatment effect modifiers. Psychotherapeutic pharmacological and combined treatments will be considered as experimental interventions and no treatment wait-list psychological pharmacological placebo treatment as usual and other active treatments will be seen as comparators. The population of patients will include adults with chronic major depression dysthymia double depression or recurrent depression without complete remission between episodes. Outcomes of the analyses are depressive symptoms associated consequences adverse events and study discontinuation. Only randomized controlled trials will be considered. Discussion Given the high prevalence and serious consequences of chronic depression and a considerable amount of existing primary studies addressing the effectiveness of different treatments the present systematic review may be of high relevance. Special attention will be given .
