Báo cáo y học: " Clinical and economic ramifications of switching antipsychotics in the treatment of schizophreniab"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Clinical and economic ramifications of switching antipsychotics in the treatment of schizophrenia | BMC Psychiatry BioMed Central Research article Clinical and economic ramifications of switching antipsychotics in the treatment of schizophrenia Douglas E Faries 1 Haya Ascher-Svanum2 Allen W Nyhuis1 and Bruce J Kinon3 Open Access Address 1US Statistics Lilly USA LLC Indianapolis IN USA 2US Outcomes Research Eli Lilly and Company Indianapolis IN USA and 3Psychosis Medical Eli Lilly and Company Indianapolis IN USA Email Douglas E Faries - Haya Ascher-Svanum - haya@ Allen W Nyhuis - nyhuis_allen@ Bruce J Kinon - bj_kinon@ Corresponding author Published 2 September 2009 Received 21 November 2008 Accepted 2 September 2009 BMC Psychiatry 2009 9 54 doi l47l-244X-9-54 p p This article is available from http l47l-244X 9 54 2009 Faries et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Switching between antipsychotic medications is common in the treatment of schizophrenia. However data on clinical and economic outcomes from antipsychotic switching in particular acute care service use is fairly limited. The goal of this research was to assess the clinical and economic ramifications of switching antipsychotics during outpatient management of schizophrenia. Methods Data from a l-year randomized open-label cost-effectiveness study involving typical and atypical antipsychotics were assessed. The study protocol permitted switching of antipsychotics when clinically warranted. The risk of crisis-related events use of acute-care services and the time to the initial use of such services were determined in outpatients who switched antipsychotics compared with those who continued with their initial medications. Health care resource utilization .

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