Evidence for genetic association of RORB with bipolar disorder | BMC Psychiatry BioMed Central Research article Open Access Evidence for genetic association of RORB with bipolar disorder Casey L McGrath1 2 Stephen J Glatt3 Pamela Sklar1 Helen Le-Niculescu4 Ronald Kuczenski5 Alysa E Doyle6 Joseph Biederman6 Eric Mick6 Stephen V Faraone3 Alexander B Niculescu 4 and Ming TTsuang 5 Address Center for Human Genetic Research Massachusetts General Hospital Boston MA USA 2Department of Biology Indiana University Bloomington IN USA 3Department of Psychiatry SUNY Upstate Medical University Syracuse NY USA Laboratory of Neurophenomics Department of Psychiatry Indiana University School of Medicine Indianapolis IN USA 5Department of Psychiatry UC San Diego La Jolla CA USA and 6Pediatric Psychopharmacology Unit Massachusetts General Hospital Psychiatric Psychopharmacology Unit Massachusetts General Hospital Harvard Medical School Boston MA USA Email Casey L McGrath - Stephen J Glatt - glatts@ Pamela Sklar - sklar@ Helen Le-Niculescu - hlenicul@ Ronald Kuczenski - rkuczenski@ Alysa E Doyle - doylea@ Joseph Biederman - biederman@ Eric Mick - emick1@ Stephen V Faraone - faraones@ Alexander B Niculescu - anicules@ MingTTsuang - mtsuang@ Corresponding authors Published 12 November 2009 Received 4 March 2009 Accepted 12 November 2009 BMC Psychiatry 2009 9 70 doi l47l-244X-9-70 p This article is available from http l47l-244X 9 70 2009 McGrath et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Bipolar disorder particularly in children is characterized by rapid cycling and switching making circadian clock genes .
