Glutamatergic deficits and parvalbumin-containing inhibitory neurons in the prefrontal cortex in schizophrenia | BioMed Central BMC Psychiatry Research article Open Access Glutamatergic deficits and parvalbumin-containing inhibitory neurons in the prefrontal cortex in schizophrenia BKY Bitanihirwe11 5 MP Lim11 JF Kelley1 T Kaneko4 and TUW Woo 1 2 3 Address Laboratory of Cellular Neuropathology McLean Hospital Belmont MA USA 2Department of Psychiatry Harvard Medical School Boston MA USA 3Department of Psychiatry Beth Israel Deaconess Medical Center Boston MA USA 4Department of Morphological Brain Science Kyoto University Kyoto Japan and 5Laboratory of Behavioral Neurobiology ETH Zurich Schorenstrasse 16 Schwerzenbach 8603 Switzerland Email BKY Bitanihirwe - MP Lim - mlim@ JF Kelley - jkelley@ T Kaneko - kaneko@ TUWWoo - wwoo@ Corresponding author fEqual contributors Published 16 November 2009 Received 2 June 2009 Accepted 16 November 2009 BMC Psychiatry 2009 9 71 doi l47l-244X-9-71 p This article is available from http l47l-244X 9 7l 2009 Bitanihirwe et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background We have previously reported that the expression of the messenger ribonucleic acid mRNA for the NR2A subunit of the N-methyl-D-aspartate NMDA class of glutamate receptor was decreased in a subset of inhibitory interneurons in the cerebral cortex in schizophrenia. In this study we sought to determine whether a deficit in the expression of NR2A mRNA was present in the subset of interneurons that contain the calcium buffer parvalbumin PV and whether this deficit was associated with a reduction in glutamatergic inputs in the prefrontal cortex PFC in schizophrenia. Methods We examined .
