Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Opioid substitution therapy in manipur and nagaland, north-east india: operational research in action | Armstrong et al. Harm Reduction Journal 2010 7 29 http content 7 1 29 HARM REDUCTION JOURNAL RESEARCH Open Access Opioid substitution therapy in manipur and nagaland north-east india operational research in action z A . 1 1 2 3 1 Gregory Armstrong Michelle Kermode Charan Sharma Biangtung Langkham Nick Crofts Abstract Background There is good evidence for the effectiveness of opioid substitution therapy OST for injecting drug users IDUs in middle and high-income countries but little evidence regarding the provision of OST by nongovernment organisations NGOs in resource-poor settings. This paper reports on outcomes of an NGO-based OST program providing sub-lingual buprenorphine to opiate dependent IDUs in two north-east Indian states Manipur and Nagaland a region where conflict under-development and injecting of heroin and Spasmoproxyvon SP are ongoing problems. The objectives of the study were 1 to calculate OST treatment retention 2 to assess the impact on HIV risk behaviours and quality of life and 3 to identify client characteristics associated with cessation of treatment due to relapse. Methods This study involves analysis of data that were routinely and prospectively collected from all clients enrolled in an OST program in Manipur and Nagaland between May 2006 and December 2007 n 2569 1853 in Manipur and 716 in Nagaland using standardised questionnaires and is best classified as operational research. The data were recorded at intake into the program after three months and at cessation. Outcome measures included HIV risk behaviours and quality of life indicators. Predictors of relapse were modelled using binary logistic regression. Results Of all clients enrolled in OST during the month of May 2006 n 713 remained on treatment after three months and after six months. Statistically significant p improvements were observed in relation to needle sharing unsafe sex incidents of detention and a range of quality of life .
