Một kỷ nguyên sinh học mới của phẫu thuật chỉnh hình đã được khởi xướng bởi những tiến bộ khoa học cơ bản có kết quả trong sự phát triển của liệu pháp gen và cách tiếp cận kỹ thuật mô để điều trị rối loạn cơ xương. Các thuật ngữ, khái niệm cơ bản và nghiên cứu hiện nay trong lĩnh vực này đang phát triển phải được hiểu bằng cách thực hành các bác sĩ phẫu thuật chỉnh hình | Perspectives on Modern Orthopaedics Gene Therapy and Tissue Engineering in Orthopaedic Surgery Douglas S. Musgrave MD Freddie H. Fu MD and Johnny Huard PhD Abstract A new biologic era of orthopaedic surgery has been initiated by basic scientific advances that have resulted in the development of gene therapy and tissue engineering approaches for treating musculoskeletal disorders. The terminology fundamental concepts and current research in this burgeoning field must be understood by practicing orthopaedic surgeons. Different gene therapy approaches multiple gene vectors a multitude of cytokines a growing list of potential scaffolds and putative stem cells are being studied. Gene therapy and tissue engineering applications for bone healing articular disorders intervertebral disk pathology and skeletal muscle injuries are being explored. Innovative methodologies that ensure patient safety can potentially lead to many new treatment strategies for musculoskeletal conditions. J Am Acad Orthop Surg 2002 10 6-15 Advances in molecular biology cell biology and polymer chemistry are providing novel approaches for treating musculoskeletal disorders. These advances are facilitating biologic approaches that complement and could even replace traditional biomechanical techniques in orthopaedic surgery. The explosion of research has resulted in a myriad of potential applications for these innovative biologic approaches. Many probably will never reach clinical fruition however effective implementation of only a few may revolutionize the way we manage certain musculoskeletal disorders. Clearly orthopaedic surgeons must have a fundamental understanding of the terminology Table 1 and techniques of these biologic advances and of current research to be able to interpret the literature direct future investigations and best serve their patients. Tissue Engineering Tissue engineering is the science of creating living tissue to replace repair or augment diseased Tissue engineering
