Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Resolution of cast nephropathy following free light chain removal by haemodialysis in a patient with multiple myeloma: a case report | Journal of Medical Case Reports BioMed Central Open Access Case report Resolution of cast nephropathy following free light chain removal by haemodialysis in a patient with multiple myeloma a case report Kolitha Basnayake 1 Colin Hutchison1 Dia Kamel1 Michael Sheaff2 Neil Ashman2 Mark Cook1 Heather Oakervee2 Arthur Bradwell3 and Paul Cockwell1 Address 1Queen Elizabeth Medical Centre University Hospital Birmingham Edgbaston Birmingham B15 2TH UK 2Barts and the London NHS Trust Whitechapel London E1 1BB UK and 3Division of Immunity and Infection University of Birmingham Edgbaston Birmingham B15 2TT UK Email Kolitha Basnayake - Colin Hutchison - CAH692@ Dia Kamel - Michael Neil Ashman - Mark Cook - Heather Oakervee - Arthur Bradwell - Paul Cockwell - Corresponding author Published 9 December 2008 Received 15 May 2008 Journal of Medical Case Reports 2008 2 380 doi 1752-1947-2-380 Accepted 9 December 2008 This article is available from http content 2 1 380 2008 Basnayake et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Acute renal failure in multiple myeloma is most frequently caused by cast nephropathy when excess monoclonal free light chains co-precipitate with Tamm-Horsfall protein in the distal nephron causing tubular obstruction. The natural history of cast nephropathy after diagnosis is unknown. This report provides supporting histological evidence that as serum free light chain concentrations fall intratubular casts
