Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Primary osteosarcoma of the urinary bladder following cyclophosphamide therapy for systemic lupus erythematosus: a case report | Journal of Medical Case Reports BioMed Central Open Access Case report Primary osteosarcoma of the urinary bladder following cyclophosphamide therapy for systemic lupus erythematosus a case report Dilek Ertoy Baydar 1 Cigdem Himmetoglu1 Sertac Yazici2 Halil Kiziloz2 and Haluk Ozen2 Address Department of Pathology Hacettepe University Hospital Ankara Turkey and 2Department of Urology Hacettepe University Hospital Ankara 06100 Turkey Email Dilek Ertoy Baydar - dertoy@ Cigdem Himmetoglu - cigdemh@ Sertac Yazici - msertacyazici@ Halil Kiziloz - halilkiziloz@ Haluk Ozen - hozen@ Corresponding author Published 29 January 2009 Received 23 August 2008 Journal of Medical Case Reports 2009 3 39 doi 1752-1947-3-39 Accepted 29 January 2009 This article is available from http content 3 1 39 2009 Baydar et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The association of systemic lupus erythematosus with malignancies is an uncommon occurrence. We present the case of an osteosarcoma of the urinary bladder developing in a patient with a prolonged history of active systemic lupus erythematosus. This is a previously unreported association. Primary osteosarcoma is an extremely rare disease in the urinary bladder. Case presentation A 24-year-old Caucasian woman with a 13-year history of systemic lupus erythematosus who had been treated with high dose immunosuppressive agents presented with pain and hematuria. A deeply invasive high-grade tumor was detected in the urinary bladder and the patient underwent radical surgery. A diagnosis of osteosarcoma was made based on the characteristic histology. Conclusion .
