Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Minimally invasive application of botulinum toxin A in patients with idiopathic rhinitis | Head Face Medicine BioMed Central Methodology Minimally invasive application of botulinum toxin A in patients with idiopathic rhinitis Saskia Rohrbach1 2 Katharina Junghans1 Sibylle Kohler1 and Rainer Laskawi 1 Open Access Address Department of Otolaryngology Head and Neck Surgery University of Gottingen Germany and 2Department of Audiology and Phoniatrics Charite Medical University of Berlin Germany Email Saskia Rohrbach - Katharina Junghans - Sibylle Kohler - Rainer Laskawi - rlaskaw@ Corresponding author Published 16 October 2009 Received 26 May 2009 Head Face Medicine 2009 5 18 doi 1746-160X-5-18 Accepted 16 October 2009 This article is available from http content 5 l l8 2009 Rohrbach et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Nasal hypersecretion due to idiopathic rhinitis can often not be treated sufficiently by conventional medication. Botulinum toxin A BTA has been injected into the nasal mucosa in patients with nasal hypersecretion with a reduction of rhinorrhea lasting for about 4 to 8 weeks. Since the nasal mucosa is well supplied with glands and vessels the aim of this study was to find out if the distribution of BTA in the nasal mucosa and a reduction of nasal hypersecretion can also be reached by a minimally invasive application by sponges without an injection. Methods Patients were randomly divided into two groups. The effect of BTA group A C D or saline as placebo group B was investigated in 20 patients with idiopathic rhinitis by applying it with a sponge soaked with BTA 40 units each nostril or saline. Subgroups C and D contained these patients of .
