Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients | Walter et al. Head Face Medicine 2010 6 11 http content 6 1 11 HEAD FACE MEDICINE RESEARCH Open Access Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients Christian Walter 1 Bilal Al-Nawas1 Norbert Frickhofen2 Heinold Gamm3 Joachim Beck3 Laura Reinsch1 Christina Blum1 Knut A Grotz1 4 and Wilfried Wagner1 Abstract Background Bisphosphonate-associated osteonecrosis of the jaws BP-ONJ is an adverse effect of bisphosphonate treatment with varying reported incidence rates. Methods In two neighboring German cities prevalence and additional factors of the development of BP-ONJ in multiple myeloma patients with bisphosphonates therapy were recorded using a retrospective RS and cross-sectional study CSS design. For the RS all patients treated from Jan. 2000 - Feb. 2006 were contacted by letter. In the CSS all patients treated from Oct. 2006 - Mar. 2008 had a physical and dental examination. Additionally a literature review was conducted to evaluate all articles reporting on BP-ONJ prevalence. PubMed search terms were bisphosphonat diphosphonate osteonecrosis prevalence and incidence. Results In the RS data from 81 of 161 patients could be obtained four patients developed BP-ONJ. In the CSS 16 of 78 patients developed BP-ONJ. All patients with BP-ONJ had received zoledronate 12 of these had had additional bisphosphonates. All except one had an additional trigger factor tooth extraction n 14 dental surgical procedure n 2 sharp mylohyoid ridge n 3 . Conclusion The prevalence of BP-ONJ may have been underestimated to date. The oral examination of all patients in this CSS might explain the higher prevalence since even early asymptomatic stages of BP-ONJ and previously unnoticed symptomatic BP-ONJ were recorded. Since nearly all patients with BP-ONJ had an additional trigger factor oral hygiene and dental care might help to reduce BP-ONJ incidence. Background Multiple myeloma is characterized by neoplastic
