Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reports | Conte-Neto et al. Head Face Medicine 2011 7 7 http content 7 1 7 HEAD FACE MEDICINE CASE REPORT Open Access Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients a critical discussion and two case reports Nicolau Conte-Neto 1 Alliny S BastosT Luis C Spolidorio2t Rosemary AC Marcantonio1t and Elcio Marcantonio JrH Abstract Background Bisphosphonate-related osteonecrosis of the jaw BRONJ is a clinical condition characterized by the presence of exposed bone in the maxillofacial region. Its pathogenesis is still undetermined but may be associated with risk factors such as rheumatoid arthritis RA . The aim of this paper is to report two unpublished cases of BRONJ in patients with RA and to conduct a literature review of similar clinical cases with a view to describe the main issues concerning these patients including demographic characteristics and therapeutic approaches applied. Methods Two case reports of BRONJ involving RA patients were discussed Results Both patients were aging female taking alendronate for more than 3 years. Lesions were detected in stage II in posterior mandible with no clear trigger agent. The treatment applied consisted of antibiotics oral rinses with chlorhexidine drug discontinuation and surgical procedures. Complete healing of the lesions was achieved. Conclusions This paper brings to light the necessity for rheumatologists to be aware of the potential risk to their patients of developing BRONJ and to work together with dentists for the prevention and early detection of the lesions. Although some features seem to link RA with oral BRONJ and act as synergistic effects more studies should be developed to support the scientific bases for this hypothesis. Background Bisphosphonates BPs are a class of drugs commonly prescribed for bone diseases due to their osteoclast inhibition property. This class of drugs has been widely used for osteoporosis and corticosteroid-induced osteoporosis in .
