Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Use of intravitreal bevacizumab in a patient with a Von Hippel-Lindau-associated retinal haemangioblastoma of the optic nerve head: a case report | Journal of Medical Case Reports BioMed Central Open Access Case report Use of intravitreal bevacizumab in a patient with a Von Hippel-Lindau-associated retinal haemangioblastoma of the optic nerve head a case report Timothy A de Klerk and David HW Steel Address Sunderland Eye Infirmary Queen Alexandra Road Sunderland Tyne and Wear SR2 9HP UK Email Timothy Ade Klerk - timothydeklerk@ David HW Steel - Corresponding author Published 29 May 2008 Received 13 May 2007 Journal of Medical Case Reports 2008 2 182 doi l752-l947-2-182 Accepted 29 May 2008 This article is available from http content 2 l l82 2008 de Klerk and Steel licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The optimum management of a capillary haemangioblastoma affecting the optic nerve head is not clear. A number of treatment modalities have been used to treat the tumours and their consequences. Ocular haemangioblastomas express high levels of vascular endothelial growth factor and levels have been correlated with tumour growth and activity. Treatment with vascular endothelial growth factor inhibitors would therefore seem a logical approach. Case presentation We describe a 23-year-old man with an exophytic capillary haemangioblastoma of the optic nerve head that was treated with intravitreal bevacizumab injections. Conclusion Unfortunately treatment with intravitreal bevacizumab on three occasions had no effect on either tumour size or exudation in this patient. Introduction The optimum management of capillary haemangioblastoma affecting the optic nerve head is not clear and indeed it has been described as one of the most difficult conditions to manage in .
