Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The WRITTEN-HEART study (expressive writing for heart healing): rationale and design of a randomized controlled clinical trial of expressive writing in coronary patients referred to residential cardiac rehabilitation | Manzoni et al. Health and Quality of Life Outcomes 2011 9 51 http content 9 1 51 HEALTH AND QUALITY OF LIFE OUTCOMES STUDY PROTOCOL Open Access The WRITTEN-HEART study expressive writing for heart healing rationale and design of a randomized controlled clinical trial of expressive writing in coronary patients referred to residential cardiac rehabilitation Gian Mauro Manzoni1 2 Gianluca Castelnuovo1 2 3 and Enrico Molinari1 2 3 Abstract Background Coronary heart disease CHD is typically associated with many cardiovascular risk factors . elevated blood pressure low health-related quality of life depression anxiety and psychological stress. Expressive writing EW has shown beneficial effects on such variables in both people from the community and in patients with a variety of chronic illnesses. However no study to date has evaluated the physical and psychological effects of the expressive writing procedure on coronary patients referred to cardiac rehabilitation CR . Methods The clinical effectiveness of a 2-week disease-related expressive writing procedure writing about one s deepest thoughts and feelings regarding the experience with heart disease compared with the standard writing task writing about one s deepest thoughts and feelings about the most traumatic or negative event experienced in the life a neutral writing condition writing about the facts regarding heart disease and its treatment and an empty control condition will be evaluated in a randomized controlled clinical trial RCT with repeated follow-up measurements at 3 6 and 12 months after discharge from CR. The primary outcome is health-related quality of life SF-12 . Secondary outcome measures are depression BDI-II anxiety BAI and post-traumatic growth PTGI . Furthermore the study will explore the moderating effects of coping styles type D personality perceived emotional support and participants evaluative ratings of the writing interventions on the main experimental effects in order to .