Bảng 8,12. Tỉ lệ sống sót tổng thể học 2 Lacy et al. [89] 3 Leung et al. [104] Leung et al. [92] Khalili et al. [90] Santoro et al. [114] Hong et al. [112] 4 Delgado et al. [157] Cook và Dehn [158] Hoffman và cộng sự | 190 R. Veldkamp et al. Table . Overall survival rates Study Follow-up Laparoscopic Open p value 2 Lacy et al. 89 43 months 82 74 NS 3 Leung et al. 104 months median 28 n 56 NS Leung et al. 92 months median 50 50 NS Khalili et al. 90 months 80 85 90 NS Santoro et al. 114 5 years 50 50 NS Hong et al. 112 Lap months Open months NA 98 NA 219 NS 4 Delgado et al. 157 42 months AR 83 SR 87 31 Cook and Dehn 158 Until patient s death 20 5 Hoffman et al. 159 2 years Node- 92 89 Node 80 Molenaar et al. 160 3 years All 59 by Dukes stage 35 A-86 B 66 c 68 D o Quattlebaum et al. 161 8 months M 10 Poulin et al. 155 Stages I-III 24 months 81 Stage IV 9 months NS not significant AR anterior resection SR sigmoid resection in stage III colon cancer patients. Follow-up data of large multicenter randomized controlled trials the CLASICC 123 COST 124 and COLOR 125 trials will provide a more definitive assessment of survival after laparoscopic vs open colon resections. In smaller nonrandomized comparative studies no significant differences in disease-free and overall survival have been observed between open and laparoscopic patient groups Tables . No significant differences were found between open and laparoscopically operated patients in a nonrandomized matched control study with 5-year follow-up 104 Another study using historical controls also showed no difference in long-term survival with survival rates of and in the open and laparoscopic arms respectively 92 . In a further six comparative studies no differences of overall survival were found between laparoscopic and open resections of colon cancer 84 88 112 114 116 126 8 The EAES Clinical Practice Guidelines on Laparoscopic Resection of Colonic Cancer 2004 191 Table . Disease-free survival rates Study Follow-up Laparoscopic Open p value 2 Lacy et al. 89 43 months 91 79 3 Leung et al. 104 5 years NS Leung et al. 92 4 years
