Hình 7,20 đơn photon phát thải tính toán cắt lớp quét (màu đỏ và xanh quy mô) trong mặt phẳng dọc của một cá nhân bình thường (trên) và năm người đàn ông 88 tuổi bị trầm cảm lâm sàng (giữa và dưới). Đại diện cho khu vực vòng tròn giảm tưới máu frontotemporal đến vỏ não. | Figure Single-photon emission computed tomography scans red and green scales in the sagittal plane of a normal individual top and an 88-year-old man with clinical depression middle and bottom . Circled areas represent reduced perfusion to the frontotemporal cortex. Printed with permission from the Department of Radiology Brigham and Women s Hospital Boston MA USA. http education online BrainSPECT Severity Figure Treatment phases in depression. Adapted with permission from Kupfer DJ. Long-term treatment of Clin Psychiatry 1991 52 suppl 28-34 2002 CRC Press LLC Number of weeks following transfer to placebo Number of weeks following transfer to placebo Figure Continuation treatment of depression after 6 months. Survival analysis comparing treatment with fluoxetine and placebo during treatment weeks 26 and 38. After 6 months of treatment continuing with fluoxetine prevents relapse of depressive symptoms in the next 3 months. Adapted with permission from Reimherr FW Amsterdam HD Quitkin FM et al. Optimal length of continuation therapy in depressions prospective assessment during long-term treatment with fluoxetine. Am J Psychiatry 1998 155 1247-53 Figure Continuation treatment of depression over 3 months. Survival analysis comparing treatment with fluoxetine and placebo during treatment weeks 12 and 3 months of open-label treatment continuing with fluoxetine prevents relapse of depressive symptoms in the next 3 months. Adapted with permission from Reimherr FW Amsterdam HD Quitkin FM et al. Optimal length of continuation therapy in depression a prospective assessment during long-term treatment with fluoxetine. Am J Psychiatry 1998 155 1247-53 Recommended Insufficient length Inadequate dose Insufficient and inadequate 250- 200- p E Q 150- 100- 50 0 III Fluoxetine Paroxetine Sertraline n 945 n 492 n 905 Figure Duration of SSRI with permission from Russell JM Berndt ER Miceli R Colucci
