Phương thức hành động của là một chất ức chế tái hấp thu serotonin yếu của phát hành và norepinephrine có thể tăng do hậu quả của hành động đối kháng STI trên trước synap a2-adrenoceptors. Ngoài ra, các khối sau khớp thần kinh thụ thể 5-HT2 | T razodone Maprotiline Bupropion T ryptophan Figure Molecular structures of trazodone maprotiline L-tryptophan and bupropion NHC CH3 3 5-HT terminal NE terminal Blocks presynaptic a2-adreno-ceptors Trazodone is a weak inhibitor of 5-HT reuptake Norepinephrine NE receptor bl 02 ai etc. Blocks postsynaptic 5-HT2 receptors Serotonin receptor 5-HTlA 5-HT2 etc. Figure The mode of action of is a weak inhibitor of serotonin reuptake and can increase norepinephrine release as a result of its antagonistic action on presynaptic a2-adrenoceptors. It also blocks postsynaptic 5-HT2 receptors 2002 CRC Press LLC Figure Side-effects of trazodone Figure The mode of action of maprotiline. Maprotiline is a modified tricyclic antidepresssant TCA that has similar efficacy to the TCAs Norepinephrine NE receptor bl Pl a etc. Serotonin receptor 5-HTlA 5-HT2 etc. 2002 CRC Press LLC Figure The side-effects of maprotiline Blurred vision 1 Glaucoma Dry mouth Cardiotoxicity Tachycardia J Orthostatic hypotension Urinary retention Vi - Constipation I - Rashes u Possible weight gain X Figure Molecular structure of mianserin 5-HT terminal T Mianserin blocks a2-autoreceptor NE terminal JỤ_ aj-heteroceptor on serotonergic nerve terminal stimulates increased release of serotonin Desensitization of 5-HT b 5-HT d receptors Norepinephrine NE receptor pl a etc. or a -receptor on serotonergic cell body or a2- heteroceptor on serotonergic nerve terminal 5-HTj and 5-HT3 receptors blocked Increased activity of 5-HT ia receptors Serotonin receptor Figure The mode of action of mianserin. Mianserin like mirtazapine enhances noradrenergic and serotonergic function by blocking the inhibitory a2-adrenoceptors on noradrenergic terminals and the a2-heteroceptors on serotonergic terminals. However mirtazapine is more effective than mianserin in enhancing serotonergic function as it increases the firing rate of serotonergic neurons. Mianserin is less potent in .
