Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Development of a patient reported outcome scale for fatigue in multiple sclerosis: The Neurological Fatigue Index (NFI-MS) | Mills et al. Health and Quality of Life Outcomes 2010 8 22 http content 8 1 22 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Development of a patient reported outcome scale for fatigue in multiple sclerosis The Neurological Fatigue Index NFI-MS Roger J Mills1 Carolyn A Young1 Julie F Pallant2 Alan Tennant3 Abstract Background Fatigue is a common and debilitating symptom in multiple sclerosis MS . Best-practice guidelines suggest that health services should repeatedly assess fatigue in persons with MS. Several fatigue scales are available but concern has been expressed about their validity. The objective of this study was to examine the reliability and validity of a new scale for MS fatigue the Neurological Fatigue Index NFI-MS . Methods Qualitative analysis of 40 MS patient interviews had previously contributed to a coherent definition of fatigue and a potential 52 item set representing the salient themes. A draft questionnaire was mailed out to 1223 people with MS and the resulting data subjected to both factor and Rasch analysis. Results Data from 635 response respondents were split randomly into an evaluation and validation sample. Exploratory factor analysis identified four potential subscales physical cognitive relief by diurnal sleep or rest and abnormal nocturnal sleep and sleepiness . Rasch analysis led to further item reduction and the generation of a Summary scale comprising items from the Physical and Cognitive subscales. The scales were shown to fit Rasch model expectations across both the evaluation and validation samples. Conclusion A simple 10-item Summary scale together with scales measuring the physical and cognitive components of fatigue were validated for MS fatigue. Background One of the symptoms causing the greatest morbidity and disability in multiple sclerosis MS is fatigue 1 2 . It has been suggested that health services should apply a broad range of approaches and repeatedly assess fatigue in persons with MS to
