Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Preferences for health outcomes associated with Group A Streptococcal disease and vaccination | Lee et al. Health and Quality of Life Outcomes 2010 8 28 http content 8 1 28 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Preferences for health outcomes associated with Group A Streptococcal disease and vaccination Grace M Lee1 2 Joshua A Salomon3 Charlene Gay1 James K Hammitt4 Abstract Background A 26-valent Group A Streptococcus GAS vaccine candidate has been developed that may provide protection against pharyngitis invasive disease and rheumatic fever. However recommendations for the use of a new vaccine must be informed by a range of considerations including parents preferences for different relevant health outcomes. Our objectives were to 1 describe parent preferences for GAS disease and vaccination using willingness-to-pay WTP and time trade-off TTO methods and 2 understand how parents implied WTP for a quality-adjusted life year QALY gained might vary depending on the particular health outcome considered . averted GAS disease vs. vaccine adverse events . Methods Telephone interviews were conducted with parents of children diagnosed with GAS pharyngitis at 2 pediatric practice sites in the Boston metropolitan area. WTP and TTO trading parental longevity for child s health questions for 2 vaccine and 4 disease-associated health states were asked using a randomly selected opening bid followed by a 2nd bid and a final open-ended question about the amount willing to pay or trade. Descriptive analyses included medians and interquartile ranges for WTP and TTO estimates. The Wilcoxon signed-rank test was used to assess differences in WTP QALY values for vaccine adverse events vs. disease states. Results Of 119 respondents 100 84 and 96 81 provided a complete set of responses for WTP and TTO questions respectively. The median WTP and discounted at 3 per year TTO values to avoid each health state were as follows local reaction 30 days systemic reaction 50 days impetigo 75 days strep throat 75 days septic arthritis 1 000
