Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Impaired sleep affects quality of life in children during maintenance treatment for acute lymphoblastic leukemia: an exploratory study | van Litsenburg et al. Health and Quality of Life Outcomes 2011 9 25 http content 9 1 25 HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Impaired sleep affects quality of life in children during maintenance treatment for acute lymphoblastic leukemia an exploratory study Raphaêle RL van Litsenburg1 Jaap Huisman2 Peter M Hoogerbrugge3 R Maarten Egeler4 Gertjan JL Kaspers5 and Reinoud JBJ Gemke1 Abstract Background With the increase of pediatric cancer survival rates late effects and quality of life QoL have received more attention. Disturbed sleep in pediatric cancer is a common clinical observation but research on this subject is sparse. In general sleep problems can lead to significant morbidity and are associated with impaired QoL. Information on sleep is essential to develop interventions to improve QoL. Methods Children 2-18 years with acute lymphoblastic leukemia ALL were eligible for this multi-center study. The Children s Sleep Habits Questionnaire CSHQ Child Health Questionnaire CHQ and Pediatric Quality of Life Inventory Acute Cancer Version PedsQL were used to assess sleep and QoL halfway through maintenance therapy. Sleep and QoL were measured during and after dexamethasone treatment on-dex and off-dex . Results Seventeen children participated age years 44 boys . Children with ALL had more sleep problems and a lower QoL compared to the norm. There were no differences on-dex and off-dex. Pain r p and worry r p showed a moderate negative association with sleep. Reduced overall QoL was moderately associated with impaired overall sleep r p and more problems with sleep anxiety r p sleep onset delay r p daytime sleepiness r p and night wakenings r p . Conclusion QoL is impaired in children during cancer treatment. The results of this study suggest that impaired sleep may be a contributing determinant. Consequently enhanced counseling and treatment of .
