Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Retrospective study of the effect of disease progression on patient reported outcomes in HER-2 negative metastatic breast cancer patients | Walker et al. Health and Quality of Life Outcomes 2011 9 46 http content 9 1 46 HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Retrospective study of the effect of disease progression on patient reported outcomes in HER-2 negative metastatic breast cancer patients 1 12 2 1 3 Mark S Walker Murad Hasan Yeun Mi Yim Elaine Yu Edward J Stepanski and Lee S Schwartzberg Abstract Background This retrospective study evaluated the impact of disease progression and of specific sites of metastasis on patient reported outcomes PROs that assess symptom burden and health related quality of life HRQoL in women with metastatic breast cancer mBC . Methods HER-2 negative mBC patients n 102 were enrolled from 7 . community oncology practices. Demographic disease and treatment characteristics were abstracted from electronic medical records and linked to archived Patient Care Monitor PCM assessments. The PCM is a self-report measure of symptom burden and HRQoL administered as part of routine care in participating practices. Linear mixed models were used to examine change in PCM scores over time. Results Mean age was 57 years with 72 of patients Caucasian and 25 African American. Median time from mBC diagnosis to first disease progression was months. Metastasis to bone 60 lung 28 and liver 26 predominated at initial metastatic diagnosis. Results showed that PCM items assessing fatigue physical pain and trouble sleeping were sensitive to either general effects of disease progression or to effects associated with specific sites of metastasis. Progression of disease was also associated with modest but significant worsening of General Physical Symptoms Treatment Side Effects Acute Distress and Impaired Performance index scores. In addition there were marked detrimental effects of liver metastasis on Treatment Side Effects and of brain metastasis on Acute Distress. Conclusions Disease progression has a detrimental impact on cancer-related symptoms. Delaying .
